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X4002

Sigma-Aldrich

黄嘌呤

BioUltra, ≥99%

别名:

2,6-二羟基嘌呤

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About This Item

经验公式（希尔记法）:
C5H4N4O2
CAS号:
69-89-6
分子量:
152.11
Beilstein:
8733
EC號碼:
200-718-6
MDL號碼:
MFCD00078453
分類程式碼代碼:
41106305
PubChem物質ID:
24902144
NACRES:
NA.51

生物源

synthetic (organic)

品質等級

200

產品線

BioUltra

化驗

≥99%

形狀

powder

雜質

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

燃燒殘留物

≤0.1%

溶解度

1 M NaOH: 0.1 M, clear, colorless to light yellow

負離子痕跡

sulfate (SO42-): <0.05%

正離子痕跡

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES 字串

O=C1NC(=O)c2nc[nH]c2N1

InChI

1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)

InChI 密鑰

LRFVTYWOQMYALW-UHFFFAOYSA-N

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一般說明

黄嘌呤及其衍生物天然存在于动物器官、酵母、土豆、咖啡豆和茶叶中。
黄嘌呤是一种嘌呤，可经由嘌呤代谢途径通过不同前体生成：
  • 鸟嘌呤脱氨酶催化的鸟嘌呤脱氨
  • 黄嘌呤氧化还原酶催化的次黄嘌呤转化

應用

本品（黄嘌呤）可作为底物测定黄嘌呤氧化酶(XOD)的抑制性。还可用于：
  • 酵母培养
  • 人类细胞系培养
  • 重组病毒克隆为大肠杆菌中的BAC(细菌人工染色体)

生化／生理作用

黄嘌呤和黄嘌呤氧化酶可用于生成超氧自由基，测定超氧化物歧化酶的活性。

特點和優勢

  • 用于测定痕量金属含量（详情参见性质栏和技术规格说明书）
  • 用于测定硫酸盐含量（详情参见性质栏和技术规格说明书）

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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分析证书(COA)

Lot/Batch Number
SLCK5817
SLCJ4094
SLCB7555
SLBB5664V
077K53071V

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Gavin C Higgins et al.
Free radical biology & medicine, 53(10), 1960-1967 (2012-09-18)
Neurons can undergo a diverse range of death responses under oxidative stress, encompassing apoptosis (caspase-dependent, programmed cell death) to various forms of caspase-independent death, including necrosis. We recently showed that primary murine cortical neurons exposed acutely to hydrogen peroxide undergo
Sergey Dikalov et al.
Biochemical pharmacology, 76(5), 589-596 (2008-07-22)
Honokiol, a compound extracted from Magnolia officinalis, has antitumor and antiangiogenic properties in several tumor models in vivo. Among the downstream pathways inhibited by honokiol is nuclear factor kappa beta (NFkappabeta). A prime physiologic stimulus of NFkappabeta is reactive oxygen
R Hille et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 9(11), 995-1003 (1995-08-01)
Xanthine oxidase and xanthine dehydrogenase are enzymes involved in the metabolism of purines and pyrimidines in various organisms. Their relationship to one another has been the subject of considerable debate, primarily because of their proposed roles in ischemia/reperfusion damage in
Avery G Frey et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(22), 8031-8036 (2014-05-21)
Although cells express hundreds of metalloenzymes, the mechanisms by which apoenzymes receive their metal cofactors are largely unknown. Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl
Carolyn F Deacon et al.
Expert opinion on investigational drugs, 19(1), 133-140 (2009-12-02)
Type 2 diabetes is a progressive disease for which current treatments are often unsatisfactory with respect to achieving therapeutic goals and unwanted side effects. Preclinical and clinical studies of linagliptin, a new oral antidiabetic agent, including data presented at Scientific
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