推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
mouse, rat, human
濃度
~1 mg/mL
技術
immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SLC18A2(6571)
mouse ... Slc18a2(214084)
rat ... Slc18a2(25549)
一般說明
Vesicular monoamine transporter 2 (VMAT2) , also known as solute carrier family 18 member A2 (SLC18A2), is a transmembrane protein that acts at nerve terminals. It is expressed in platelets and in central, peripheral and enteric neurons. The gene encoding VMAT2 consists of 16 exons and is mapped to human chromosome 10q25.
免疫原
synthetic peptide corresponding an internal sequence of human VMAT2. This sequence is identical in mouse and rat.
應用
Anti-VMAT2 antibody produced in rabbit has also been used in immunofluorescence.
Anti-VMAT2 antibody produced in rabbit has been used in western blot analysis.
生化／生理作用
Vesicular monoamine transporter 2 (VMAT2) modulates the release of neurotransmitters like dopamine, serotonin and γ-amino butyric acid. It has a role in the accumulation of neurotransmitters in synaptic vesicles to prevent toxicity. VMAT2 has been linked to tardive dyskinesia and may be associated with Parkinson′s disease.
外觀
solution in phosphate buffered saline, containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
Longo F
Acta Neuropathologica Communications, 5, 22-22 (2017)
Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia.
Zai CC
Journal of Psychiatric Research, 47, 1760-1765 (2013)
N E Straznicky et al.
Obesity science & practice, 2(1), 13-23 (2016-11-05)
The objective of this study was to examine the cross-sectional relationship between the expression of norepinephrine transporter (NET), the protein responsible for neuronal uptake-1, and indices of glycaemia and hyperinsulinaemia, in overweight and obese individuals. Thirteen non-medicated, non-smoking subjects, aged
Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease.
Brighina L
Neurobiology of Aging, 34, e9-13 (2013)
Vesicular monoamine transporter, type 2 (VMAT2) expression as it compares to insulin and pancreatic polypeptide in the head, body and tail of the human pancreas.
Freeby M
Islets, 4, 393-397 (2012)
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