推荐产品
形狀
crystals
品質等級
顏色
off-white
mp
115-118 °C
135-137 °C
溶解度
DMSO: soluble
儲存溫度
2-8°C
SMILES 字串
CCC1(NC(=O)N(C)C1=O)c2ccccc2
InChI
1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)
InChI 密鑰
GMHKMTDVRCWUDX-UHFFFAOYSA-N
基因資訊
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
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生化／生理作用
CYP2B6 and CYP2C19 substrate; anticonvulsive, antiepileptic.
包裝
Bottomless glass bottle. Contents are inside inserted fused cone.
準備報告
(±)-Mephenytoin is soluble in DMSO.
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Yasuhiro Uno et al.
The Journal of veterinary medical science, 72(2), 225-228 (2009-11-27)
The macaque is widely used for investigation of drug metabolism due to its evolutionary closeness to the human. However, the genetic backgrounds of drug-metabolizing enzymes have not been fully investigated; therefore, identification and characterization of drug-metabolizing enzyme genes are important
Yajing Hu et al.
Pharmacogenetics and genomics, 23(2), 78-83 (2012-12-18)
We investigated whether human pharmacogenetic factors could be characterized using chimeric NOG mice expressing a thymidine kinase transgene (TK-NOG) with 'humanized' livers. The rate of human-specific metabolism of two drugs was measured in chimeric mice reconstituted with human hepatocytes with
Michael Zientek et al.
Journal of pharmacological and toxicological methods, 58(3), 206-214 (2008-07-19)
Inhibition of cytochrome P450 (CYP) is a principal mechanism for metabolism-based drug-drug interactions (DDIs). This article describes a robust, high-throughput CYP-mediated DDI assay using a cocktail of 5 clinically relevant probe substrates with quantification by liquid chromatography/tandem mass spectrometry (LC/MS-MS).
Huijuan Wang et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(5), 830-837 (2011-02-18)
CYP2C19 is a highly polymorphic enzyme that affects the metabolism of a wide range of therapeutic drugs. Almost all the identified alleles of CYP2C19 are derived from nonsynonymous single nucleotide polymorphisms (nsSNPs). The objective of this study was to functionally
Susanne Löfgren et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(5), 955-962 (2008-02-16)
CYP2C19 is an important enzyme for human drug metabolism, and it also participates in the metabolism of endogenous substrates, whereas the CYP2C18 enzyme is not expressed in human liver despite high mRNA expression. Mice transgenic for the human CYP2C18 and
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