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生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥90% (SDS-PAGE)
形狀
lyophilized powder
分子量
40 kDa
技術
western blot: suitable
適合性
suitable for Western blot
UniProt登錄號
應用
cell analysis
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... MAPT(4137)
一般說明
Research area: Neuroscience
Tau-383 belongs to the neuronal microtubule-associated protein family and is found in the axons of the CNS (central nervous system). It is encoded by the MAPT (microtubule associated protein tau) gene on chromosome 17q21 and exists in the form of 6 isoforms produced by the alternative splicing of m-RNA transcripts of MAPT (microtubule associated protein tau).
Tau-383 belongs to the neuronal microtubule-associated protein family and is found in the axons of the CNS (central nervous system). It is encoded by the MAPT (microtubule associated protein tau) gene on chromosome 17q21 and exists in the form of 6 isoforms produced by the alternative splicing of m-RNA transcripts of MAPT (microtubule associated protein tau).
應用
The product can be utilized for systemic identification of Phosphorylation sites in microtubule-associated protein tau by using checkpoint kinases Chk1 and Chk2 in vitro.
生化／生理作用
Microtubule-associated protein tau is mainly involved in promoting the assembly and stability of microtubules in axons. The N terminal domain of tau protein is responsible for many important functions including regulation of microtubule dynamics, and spacing between microtubules and cell compartments. While the proline rich domain of the tau protein plays a key role in neuronal signaling, functioning, and maintenance of the cytoskeleton. The interaction between tau and the microtubules plays a crucial role in regulating cell signaling, synaptic plasticity, and genomic stability. Thus, an impaired interaction between Tau and microtubules leads to the development of several neurodegenerative diseases.
Isoform of Tau, variant 0N4R, having 4 microtubule binding repeats (R) and no amino terminal inserts (N)
重構
Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Jhoana Mendoza et al.
Journal of proteome research, 12(6), 2654-2665 (2013-04-05)
Hyperphosphorylation of microtubule-associated protein tau is thought to contribute to Alzheimer's disease (AD) pathogenesis. We previously showed that DNA damage-activated cell cycle checkpoint kinases Chk1 and Chk2 phosphorylate tau at an AD-related site and enhance tau toxicity, suggesting potential roles
A Himmler et al.
Molecular and cellular biology, 9(4), 1381-1388 (1989-04-01)
Tau proteins consist of a family of proteins, heterogeneous in size, which associate with microtubules in vivo and are induced during neurite outgrowth. In humans, tau is one of the major components of the pathognomonic neurofibrillary tangles in Alzheimer's disease
Jesus Avila et al.
Physiological reviews, 84(2), 361-384 (2004-03-27)
The morphology of a neuron is determined by its cytoskeletal scaffolding. Thus proteins that associate with the principal cytoskeletal components such as the microtubules have a strong influence on both the morphology and physiology of neurons. Tau is a microtubule-associated
M Goedert et al.
Neuron, 3(4), 519-526 (1989-10-01)
We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with
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