T7830

TFLLR-NH2 trifluoroacetate salt

>98% (HPLC)

• 别名: L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt, Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt
• 经验公式（希尔记法）: C₃₁H₅₃N₉O₆ · xC₂HF₃O₂
• CAS号: 1313730-19-6
• 分子量: 647.81 (free base basis)
• MDL號碼: MFCD05663482
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329826874
• NACRES: NA.77

属性

• 化驗: >98% (HPLC)
• 形狀: lyophilized powder
• 顏色: white to tan
• 溶解度: H₂O: >2 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
• InChI: 1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
• InChI 密鑰: QVNWOGSDGQDGHP-MKVNCOEFSA-N

说明

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

應用

TFLLR-NH₂ trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

生化／生理作用

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

準備報告

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable