T6829

TUG-424

≥98% (HPLC)

• 别名: 3-(4-(o-Tolylethynyl)phenyl)propanoic acid
• 经验公式（希尔记法）: C₁₈H₁₆O₂
• CAS号: 1082058-99-8
• 分子量: 264.32
• MDL號碼: MFCD12912449
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329826854
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 溶解度: DMSO: >10 mg/mL; H₂O: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: Cc1ccccc1C#Cc2ccc(CCC(O)=O)cc2
• InChI: 1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
• InChI 密鑰: FODHWOBAQBTTFS-UHFFFAOYSA-N

说明

生化／生理作用

TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.

GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.

安全信息

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H319,H410
• 防範說明: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves