所有图片(1)
About This Item
经验公式（希尔记法）:
C22H17ClN2
CAS号:
分子量:
344.84
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
off-white
溶解度
DMSO: 2 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
InChI 密鑰
KBFUQFVFYYBHBT-UHFFFAOYSA-N
應用
TRAM-34 已被用于研究其对预防球囊血管成形术后血管再狭窄的作用。
生化／生理作用
TRAM-34 对 IK Ca 1 通道的选择性是其他 K + 通道的 100 倍 (K d = 20 nM)（卡律蝎毒素，K d = 5 nM, 克霉唑，K d = 70 nM；尼群地平 K d = 900 nM）。此外，已知 TRAM-34 可抑制人 T 淋巴细胞的活化 。
TRAM-34 是中电导 Ca2+ 激活 K+ 通道的强效抑制剂。
準備報告
TRAM-34 可溶于 DMSO (2 mg/mL)。但不溶于水。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 4
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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