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Merck

T5575

Sigma-Aldrich

TG003

≥98% (HPLC)

别名:

(1Z)-1-(3-乙基-5-甲氧基-2(3H)-苯并噻唑亚基)-2-丙酮

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About This Item

经验公式(希尔记法):
C13H15NO2S
分子量:
249.33
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

mp

132-132.5 °C

溶解度

DMSO: 33 mg/mL

儲存溫度

2-8°C

SMILES 字串

CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O

InChI

1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-

InChI 密鑰

BGVLELSCIHASRV-QPEQYQDCSA-N

應用

TG003已被用于PAC1细胞培养体外激酶检测中。
TG003已被用于开发可影响mRNA剪接1的筛选底物的检测体系。

生化/生理作用

TG003可调节可变剪接并降低SF2/ASF1的磷酸化。
TG003,一种CLK(cdc2样激酶)家族抑制剂,可用作杜氏肌营养不良症的药物。
Cdc2样激酶(Clk)的有效、特异、可逆及ATP竞争性抑制剂。对于mClk1/Sty的Ki = 10 nM;对于mClk4、mClk1、mClk2和mClk3分别的IC50 = 15 nM、20 nM、200 nM和> 10 mM。

包裝

在氮气保护下封装。

準備報告

TG003可以33 mg/ml溶于DMSO。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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其他客户在看

Slide 1 of 2

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Yukiya Sako et al.
Scientific reports, 7, 46126-46126 (2017-05-31)
Duchenne muscular dystrophy (DMD) is a fatal progressive muscle-wasting disease. Various attempts are underway to convert severe DMD to a milder phenotype by modulating the splicing of the dystrophin gene and restoring its expression. In our previous study, we reported
Ken-ichi Fujita et al.
Bioscience, biotechnology, and biochemistry, 76(6), 1248-1251 (2012-07-14)
A number of proteins complete mRNA processing in the nucleus, thus, inhibitor of mRNA processing is worth finding to analyze the mechanism of mRNA maturation in detail. Here, we established a monitoring system for mRNA processing using a test compound
The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming
Tang H W, et al.
Cell Metabolism, 27(5), 1040-1054 (2018)
The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators
Llorian M, et al.
Nucleic Acids Research, 44(18), 8933-8950 (2016)
Deciphering targeting rules of splicing modulator compounds: case of TG003
Sakuma M, et al.
BMC Molecular Biology, 16(1), 16-16 (2015)

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