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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
mp
132-132.5 °C
溶解度
DMSO: 33 mg/mL
儲存溫度
2-8°C
SMILES 字串
CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O
InChI
1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
InChI 密鑰
BGVLELSCIHASRV-QPEQYQDCSA-N
應用
TG003已被用于PAC1细胞培养和体外激酶检测中。
TG003已被用于开发可影响mRNA剪接1的筛选底物的检测体系。
生化/生理作用
TG003可调节可变剪接并降低SF2/ASF1的磷酸化。
TG003,一种CLK(cdc2样激酶)家族抑制剂,可用作杜氏肌营养不良症的药物。
Cdc2样激酶(Clk)的有效、特异、可逆及ATP竞争性抑制剂。对于mClk1/Sty的Ki = 10 nM;对于mClk4、mClk1、mClk2和mClk3分别的IC50 = 15 nM、20 nM、200 nM和> 10 mM。
包裝
在氮气保护下封装。
準備報告
TG003可以33 mg/ml溶于DMSO。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Scientific reports, 7, 46126-46126 (2017-05-31)
Duchenne muscular dystrophy (DMD) is a fatal progressive muscle-wasting disease. Various attempts are underway to convert severe DMD to a milder phenotype by modulating the splicing of the dystrophin gene and restoring its expression. In our previous study, we reported
Bioscience, biotechnology, and biochemistry, 76(6), 1248-1251 (2012-07-14)
A number of proteins complete mRNA processing in the nucleus, thus, inhibitor of mRNA processing is worth finding to analyze the mechanism of mRNA maturation in detail. Here, we established a monitoring system for mRNA processing using a test compound
The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming
Cell Metabolism, 27(5), 1040-1054 (2018)
The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators
Nucleic Acids Research, 44(18), 8933-8950 (2016)
Deciphering targeting rules of splicing modulator compounds: case of TG003
BMC Molecular Biology, 16(1), 16-16 (2015)
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