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化驗
≥97% (HPLC)
形狀
powder
顏色
orange to dark red
溶解度
methanol: 5 mg/mL, clear, red-orange to red
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
2-8°C
SMILES 字串
Cc1coc2-c3ccc4c(CCCC4(C)C)c3C(=O)C(=O)c12
InChI
1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChI 密鑰
HYXITZLLTYIPOF-UHFFFAOYSA-N
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一般說明
丹参酮IIA (Tan IIA) 是一种天然二萜醌, 是来源于 丹参根提取物的一种亲脂性成分。
應用
丹参酮IIA 已被用于：
- 在卵巢切除术诱导的骨质疏松小鼠模型中测试其对破骨细胞分化的影响
- 测试其对小神经胶质细胞的影响并研究其对缺血再灌注损伤大鼠脑的神经保护作用
- 在体外 和体内模型中研究其对急性髓系白血病（AML）增殖、凋亡和自噬的影响
- 研究其对ATDC5细胞中脂多糖（LPS）诱导的炎症损伤的抗炎和保护作用
生化／生理作用
中药丹参（Salvia miltiorrhiza）的菲醌类成分。抗炎。抗氧化。对多种细胞系（包括人神经胶质瘤细胞）具有细胞毒性。
丹参酮IIA通过增强血管生成防止心血管疾病。它还具有神经保护、抗癌、抗糖尿病和抗肥胖特性。Tan-IIA 在调节免疫细胞的发育和功能方面起重要作用。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Rui Guo et al.
Drug design, development and therapy, 14, 4735-4748 (2020-11-17)
Salvia miltiorrhiza: (Danshen) is a significant (traditional Chinese medication) natural remedy, enhancing blood circulation and clear blood stasis. In this view, it is widely used against several heart diseases, eg, cardiomyopathy, arrhythmia, and congenital heart defects. Tanshinone IIA (tan-IIA) is
Weiyang Tang et al.
Journal of separation science, 41(17), 3372-3381 (2018-07-15)
A hydrophobic ionic liquid modified thermoresponsive molecularly imprinted monolith was synthesized using N-isopropylacrylamide as a thermoresponsive monomer and a long-chain hydrophobic ionic liquid as an auxiliary modification monomer. The ionic-liquid-modified thermoresponsive molecularly imprinted polymer was characterized by scanning electron microscopy
Li Cheng et al.
American journal of translational research, 10(5), 1457-1468 (2018-06-12)
Osteoporosis is a common disease associated with age and menopausal status. Postmenopausal osteoporosis is the most common type of primary osteoporosis and is accompanied by increased risk of osteoporotic fracture. Natural and herbal compounds have long been used to prevent
Ming-Jaw Don et al.
Journal of natural products, 68(7), 1066-1070 (2005-07-26)
Five new N-containing compounds, neosalvianen (1), salvianen (2), salvianan (3), salviadione (4), and 5-(methoxymethyl)-1H-pyrrole-2-carbaldehyde (5), were isolated from Salvia miltiorrhiza. Their structures were mainly established by spectroscopic methods. Neosalvianen (1) and its analogues (6a, 6b) were synthesized for spectroscopic data
Luan Luan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 103, 628-636 (2018-04-22)
Osteoarthritis is the most common bone-joint disease in middle and older people all over the world. Tanshinone IIA (Tan IIA) is the main lipophilic diterpenoid isolated from the root of Salvia miltiorrhiza Bunge (Lamiaceae). This study analyzed the protective effects
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