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化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to tan
溶解度
DMSO: ≥20 mg/mL
起源
Servier
儲存溫度
room temp
SMILES 字串
O.[Na+].CN1c2ccccc2C(NCCCCCCC([O-])=O)c3ccc(Cl)cc3S1(=O)=O
InChI
1S/C21H25ClN2O4S.Na.H2O/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);;1H2/q;+1;/p-1
InChI 密鑰
HNTRDGDHBBFLPG-UHFFFAOYSA-M
一般說明
噻奈普汀是一种μ-阿片受体（MOR）和δ-阿片受体（DOR）激动剂。
應用
水合噻奈普汀钠盐已被用于在人胚肾293细胞系中进行的5-羟色胺转运体（SERT）测定中作为5-羟色胺再摄取增强剂（SSRE）阳性对照。
生化／生理作用
噻奈普汀是一种可增强5-羟色胺再摄取的三环类抗抑郁药。这种药物会影响到神经保护、神经兴奋性、记忆和焦虑。然而，噻奈普汀与不良的精神运动、认知、心血管、睡眠和体重影响无关。该药物具有较低的滥用倾向性，以及正向的药代动力学曲线。
噻奈普汀是最少参与到药物相互作用的，因为它并不会被肝脏中的细胞色素P450系统所代谢。在海马体和杏仁核中，噻奈普汀可参与到谷氨酸能传递过程并引起神经可塑性。
準備報告
噻奈普汀钠盐水合物可溶于 DMSO，浓度大于或等于 20 mg/ml。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Gerardo G Piroli et al.
Experimental neurology, 241, 184-193 (2012-12-25)
Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients.
Katarzyna Socała et al.
Progress in neuro-psychopharmacology & biological psychiatry, 38(2), 121-126 (2012-03-13)
Sildenafil, a selective phosphodiesterase type 5 inhibitor, has recently been reported to abolish anti-immobility action of antidepressant drugs, i.e., bupropion, venlafaxine and S-citalopram, in the forced swim test in mice. The present study was designed to investigate the influence of
Zorana Oreščanin-Dušić et al.
Acta physiologica Hungarica, 99(2), 140-147 (2012-08-02)
Tianeptine is a novel anti-depressant with an efficacy equivalent to that of classical anti-depressants. Additional beneficial effects include neuroprotection, anti-stress and anti-ulcer properties whose molecular mechanisms are still not completely understood but may involve changes in the anti-oxidant defence system.
Metabolic and Behavioral Effects of Serotonergic Antidepressants in Rats Exposed to Swim Endurance Stress.
Gitay, M., and Bano, S.
Journal of Basic & Applied Sciences, 9, 269-275 (2013)
N M Maksimova et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(11 Pt 2), 41-47 (2012-12-22)
Peculiarities of the dynamics of anxious depression under the treatment with selective serotonergic antidepressants with different mechanisms of action on the serotonin reuptake were investigated. It was examined 61 patients with anxious depression (ICD-10 F32.1, F33.1, F34.1) treated with zoloft
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