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生物源
human
重組細胞
expressed in CHO cells
化驗
≥98% (SDS-PAGE)
形狀
lyophilized
分子量
monomer 39 kDa by calculation
包裝
pkg of 100 μg
雜質
<0.06 EU/μg endotoxin, tested
顏色
white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... CTLA4(1493)
一般說明
CD152 (CTLA-4 (cytotoxic T-lymphocyte associated protein 4)) and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain.
CD152 and CD28 are both expressed on the cell surface as homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
CD152 and CD28 are both expressed on the cell surface as homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
生化／生理作用
CD152 (CTLA-4) and CD28, together with their ligands B7-1 and B7-2 (cluster of differentiation 80 and 86 respectively), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CTLA-4 (cytotoxic T-lymphocyte associated protein 4) is known to prevent immune responses, and its deficiency causes fatal lymphoproliferation in mouse models. Overexpression of the gene is observed in rheumatoid arthritis. Mutation in CTLA-4 is associated with insulin-dependent (type 1) diabetes mellitus, Grave′s disease and Hashimoto′s thyroiditis.
外觀
Lyophilized from 0.2 μm-filtered solution in PBS.
重構
Reconstitute at 100 μg/mL in sterile PBS.
其他說明
The extracellular domain of human CD152 [CTLA-4] (aa 37-160) is fused to the N-terminus of the Fc region of a mutant human IgG1.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance.
Romo-Tena J, et al.
Autoimmunity Reviews, 12(12), 1171-1176 (2013)
Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection.
Steiner K, et al.
Clinical and Experimental Immunology, 115(3), 451-451 (1999)
T-cell regulation by CD28 and CTLA-4.
Alegre M L, et al.
Nature Reviews: Immunology, 1(3), 220-220 (2001)
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