SRP6067

Cyclophilin D human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• 别名: CYP-40, CYPD, PPID, Peptidyl prolyl isomerase D
• 分類程式碼代碼: 12352200
• NACRES: NA.32

属性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥95% (SDS-PAGE)
• 形狀: liquid
• 分子量: 42.9 kDa
• 包裝: pkg of 100 μg
• NCBI登錄號: Q08752
• UniProt登錄號: Q08752
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... PPID(5481)

说明

一般說明

Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family. It is a mitochondrial matrix protein and a component of the mitochondrial permeability transition pore (MPTP).

應用

Human cyclophilin D has been used to study the effects of muscle denervation on the opening of the permeability transition pore and on the expression of cyclophilin D in rats.

生化／生理作用

Cyclophilin D catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. It plays a decisive role in mitochondrial permeability transition. The protein can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.

外觀

1 mg/mL solution in PBS (pH 7.4) containing 10% glycerol.

準備報告

Centrifuge the vial prior to opening.

其他說明

MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable