推荐产品
生物源
Xenopus sp.
重組細胞
expressed in baculovirus infected Sf9 cells
產品線
PRECISIO®
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
186-290 nmol/min·mg
分子量
~103 kDa
NCBI登錄號
應用
cell analysis
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
Xenopus laevis ... prkca(447031)
一般說明
Protein kinase C-α (PKC-α) is a member of the PKC family of serine- and threonine-specific protein kinases that can be activated by calcium and the secondary messenger diacylglycerol. The protein is expressed in the dorsal ectoderm of Xenopus.
生化/生理作用
Protein kinase C-α (PKC-α) has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint and cell volume control. It has been identified as a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes.
外觀
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
準備報告
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
法律資訊
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Protein kinase C isozymes have distinct roles in neural induction and competence in Xenopus.
Cell, 68(6), 1021-1029 (1992)
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature Medicine, 10(3), 248-254 (2004)
aPKC phosphorylates p27Xic1, providing a mechanistic link between apicobasal polarity and cell-cycle control.
Developmental Cell, 31(5), 559-571 (2014)
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