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重組細胞
expressed in baculovirus infected Sf9 cells
產品線
PRECISIO® Kinase
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
11.9-16.1 nmol/min·mg
分子量
~132 kDa
NCBI登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... EIF2AK4(440275)
一般說明
Eukaryotic translation initiation factor 2-α kinase 4 (EIF2AK4), also known as GCN2 is an enzyme encoded by EIF2AK4 gene in humans. In mouse, EIF2AK4 is widely expressed with prominent expression in liver and brain.
生化／生理作用
Eukaryotic translation initiation factor 2-α kinase 4 (EIF2AK4) is responsible for phosphorylation of the a subunit of the eukaryotic initiation factor 2 (eIF2α). The EIF2AK4 eIF2-α kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. The protein p58IPK inhibits EIF2AK4 activity. EIF2AK4 is linked to pulmonary veno-occlusive disease (PVOD) development and its pathway is associated with diseases such as cancer and Alzheimer′s disease. The protein affects many aspects of cellular physiology in response to a number of stresses such as starvation. Mutation in EIF2AK4 may cause autosomal-recessive pulmonary capillary hemangiomatosis (PCH). EIF2AK4 causes tumor growth and angiogenesis by expression of vascular endothelial growth factor (VEGF).
外觀
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
準備報告
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
法律資訊
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
EIF2AK4 mutations in pulmonary capillary hemangiomatosis
D Hunter Best
Chest, 145 (2013)
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase
J J Berlanga
European Journal of Biochemistry (2014)
p58IPK is an inhibitor of the eIF2a kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Anne Roobol
The Biochemical Society, 465 (2014)
mino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway
Yugang Wang
Neoplasia (2013)
EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension
Melanie Eyries
Nature Genetics, 46(46) (2013)
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