推荐产品
生物源
human
重組細胞
expressed in E. coli
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
分子量
~76 kDa
NCBI登錄號
應用
cell analysis
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... TUBB(203068)
一般說明
Tubulin-β 1 (TUBB1) protein is a major constituent of microtubules. Previous work suggested that the "microtubule binding domain" of tau (composed of three or four imperfect 18-amino acid repeats, separated by 13- or 14-amino acid inter-repeat regions) can bind to the C-terminal ends of both α and β tubulin monomers. It is found in hematopoietic cells and platelet marginal bands. The gene encoding TUBB1 is localized on human chromosome 6p21.
應用
GST tagged tubulin has been used in Western blotting and in mass spec as a control.
生化／生理作用
Tubulin-β 1 (TUBB1) interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. It has a role in the formation of the cytoskeleton. Studies revealed that TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded that TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance.
外觀
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
準備報告
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Root morphogenic pathways in Eucalyptus grandis are modified by the activity of protein arginine methyltransferases
Krista l
BMC plant biology (2017)
The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance
Andreas Prokop
Neural Dev. (2013)
The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP)
Paula A
British Journal of Haematology (2013)
An expressed beta-tubulin gene, TUBB, is located on the short arm of human chromosome 6 and two related sequences are dispersed on chromosomes 8 and 13.
Floyd_smith G
Experimental Cell Research (1986)
Helen K Berrieman et al.
The Lancet. Oncology, 5(3), 158-164 (2004-03-09)
beta-tubulin is the target of various antitubulin agents used in the treatment of cancer. After beta tubulin was shown to confer resistance to antitubulin agents in established cell lines, several studies have investigated the DNA sequence of this compound in
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