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生物源
human
重組細胞
expressed in CHO cells
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
80.0-90.0 kDa
包裝
pkg of 10 μg
雜質
<0.1 EU/μg endotoxin, tested
顏色
white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... AOC3(8639)
一般說明
VAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaquinone oxidase family. Recombinant VAP-1 is a mixture of monomeric and disulfide linked homodimeric forms of a 737 amino acid polypeptide corresponding to amino acids 27 to 763 of the VAP-1 precursor. The gene AOC3 (amine oxidase, copper containing 3) encodes a 170kDa homodimeric sialylated glycoprotein, VAP-1 (vascular adhesion protein-1), that is abundantly expressed in high endothelial venules (HEV) of peripheral lymph nodes. It is expressed in capillaries of non-lymphatic human tissues, such as kidney and heart. It is also expressed on on adipocytes, dendritic cells and smooth muscle cells.
生化／生理作用
The protein VAP-1 (vascular adhesion protein-1) belongs to the group of semicarbazide sensitive amine oxidases (SSAO) that catalyze the formation of reactive oxygen species. It is a unique adhesion molecule that participates in inflammatory leukocyte recruitment in blood vessels. It functions in leukocyte extravasation to inflamed tissues. In the human eye, it has been associated with ocular inflammatory diseases, such as uveitis, age-related macular degeneration, and diabetic retinopathy. Its expression has been observed to be altered in several diseases, such as rheumatoid arthritis, diabetes, and atherosclerosis.
外觀
Lyophilized from 10 mM Sodium Phosphate, pH 7.8.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A J Gearing et al.
Immunology today, 14(10), 506-512 (1993-10-01)
The demonstration of soluble isoforms of adhesion molecules has added a layer of complexity of our understanding of lymphoid-endothelial cell interactions. This is especially true in the light of observations which show levels of these isoforms to be raised during
VAP-1-mediated M2 macrophage infiltration underlies IL-1?- but not VEGF-A-induced lymph- and angiogenesis.
Nakao S
The American Journal of Pathology, 178, 1913-1921 (2011)
Lama Almulki et al.
Experimental eye research, 90(1), 26-32 (2009-09-19)
Recently we showed a critical role for Vascular Adhesion Protein-1 (VAP-1) in rodents during acute ocular inflammation, angiogenesis, and diabetic retinal leukostasis. However, the expression of VAP-1 in the human eye is unknown. VAP-1 localization was therefore investigated by immunohistochemistry.
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