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Key Documents

SRP2094

Sigma-Aldrich

Fos-related antigen 1 human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

别名:

FRA, FRA1, fra-1

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.26

生物源

human

重組細胞

expressed in insect cells

化驗

≥70% (SDS-PAGE)

形狀

frozen liquid

分子量

~31.2 kDa

包裝

pkg of 5 μg

儲存條件

avoid repeated freeze/thaw cycles

濃度

350 μg/mL

顏色

colorless to clear

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... FOSL1(8061)

生化/生理作用

The fos-related antigen 1 (Fra-1, or FosL1: Fos-like antigen 1) is a member of the Fos onco-protein family and a component of AP-1 transcription factor. Similar to other members of the family, Fra-1 contains a leucine zipper domain and a highly conserved C-terminal region. Transcription of Fra-1 gene is regulated by multiple cis-elements and 12-O-tetradecanoylphorbol-13-acetate (TPA). Fra-1 expression is associated with proliferation and invasiveness of breast cancer cells and other cancer cells.

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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D R Cohen et al.
Genes & development, 3(2), 173-184 (1989-02-01)
fra-1 encodes a serum-inducible protein (Fra-1) that is antigenically related to Fos. We have characterized Fra-1 expression in serum-stimulated cells using antibodies raised against several regions of this protein. Fra-1, expressed transiently in COS cells or in serum-stimulated rat fibroblasts
Pavan Adiseshaiah et al.
The Journal of biological chemistry, 278(48), 47423-47433 (2003-09-19)
Recent studies indicate a potential role for Fra-1, a heterodimeric partner of activator protein 1 (AP1), in toxicant-induced epithelial injury, repair, and cellular transformation. Here, we have investigated the transcriptional regulation of fra-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human bronchial epithelial
M Matsui et al.
Oncogene, 5(3), 249-255 (1990-03-01)
cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues

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