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Merck
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Key Documents

SRP2031

Sigma-Aldrich

CTF1 human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

别名:

CTF, CTF/NFI, NF-1, NF-I

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.26

生物源

human

重組細胞

expressed in insect cells

化驗

≥70% (SDS-PAGE)

形狀

frozen liquid

分子量

~56.4 kDa

包裝

pkg of 5 μg

濃度

500 μg/mL

顏色

colorless to clear

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... CTF-1(1489)

生化/生理作用

The CCAAT-box binding protein 1 (CTF1, also called NF-I or NF-1) is a proline-rich transcription activator. It selectively activates transcription of genes that contain GCCAAT consensus sequence in promoter region, including human Ha-Ras, alpha-globin, hsp70 and many other cellular and viral genes. Cloning and functional characterization of the protein revealed that CTF1 contains an N-terminal DNA binding domain and a C-terminal proline-rich activation domain. CTF1 was shown to interact with the general transcription factor IIB (TFIIB) and facilitate the recruitment of TFIIB to TBP-DNA complexes, with the forkhead thyroid transcription factor TTF2 to regulate hormone–dependent transcription of thyroperoxidase gene, as well as other receptor proteins to synergize hormone receptor-responsive activation.

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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N Mermod et al.
Cell, 58(4), 741-753 (1989-08-25)
Human CTF/NF-I consists of a family of CCAAT box binding proteins that activate both transcription and DNA replication. Analysis of cDNA mutants expressed in E. coli and Drosophila cells reveals that the N-terminal portion of CTF-1 is sufficient for site-specific
K A Jones et al.
Cell, 48(1), 79-89 (1987-01-16)
Transcription factor CTF, which is responsible for selective recognition of eukaryotic promoters that contain the sequence CCAAT, was purified to apparent homogeneity by sequence-specific DNA affinity chromatography. Binding sites for CTF in the human Ha-ras and alpha-globin promoters were highly
C Santoro et al.
Nature, 334(6179), 218-224 (1988-07-21)
The CTF/NF-I group of cellular DNA binding proteins recognizes the sequence GCCAAT and is implicated in eukaryotic transcription as well as DNA replication. Molecular analysis of human CTF/NF-I complementary DNA clones reveals multiple messenger RNA species containing alternative coding regions
Alejandro Aranda et al.
Cellular and molecular life sciences : CMLS, 71(23), 4637-4651 (2014-05-06)
We report a new method to generate high-expressing mammalian cell lines in a quick and efficient way. For that purpose, we developed a master cell line (MCL) containing an inducible alphavirus vector expressing GFP integrated into the genome. In the

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