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Key Documents

SRP0394

Sigma-Aldrich

EZH2/EED/SUZ12/RbAp48 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

重組細胞

expressed in baculovirus infected Sf9 cells

化驗

≥90% (SDS-PAGE)

形狀

aqueous solution

分子量

48 kDa (RbBP5)
51 kDa (EED)
86 kDa (EZH2)
87 kDa (SUZ12)

包裝

pkg of 50 μg

運輸包裝

dry ice

儲存溫度

−70°C

一般說明

Complex of human EZH2 (GenBank Accession No. NM_004456), amino acids 2-end with N-terminal His-tag, MW= 86 kDa; human EED (GenBank Accession No. NM_003797) amino acids 2-end with N-terminal Flag-tag, MW= 51 kDa, human SUZ12 (GenBank Accession No. NM_015355) amino acids 2-end with N-terminal His-tag, MW = 87 kDa, and human RbAp48 (GenBank Accession No. NM_005610) amino acids 2-end with N-terminal His-tag, MW = 48 kDa, co-expressed in Baculovirus expression system.

應用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Rakotobe, D. et al.
Journal of Virology, 5, 32-32 (2008)
Sooryanarayana Varambally et al.
Science (New York, N.Y.), 322(5908), 1695-1699 (2008-11-15)
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain

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