SML3686

MYF-03-176

≥98% (HPLC)

• 别名: 2-Fluoro-1-[(3R,4R)-3-(2-pyrimidinylamino)-4-[[4-(trifluoromethyl)phenyl]methoxy]-1-pyrrolidinyl]-2-propen-1-one
• 经验公式（希尔记法）: C₁₉H₁₈F₄N₄O₂
• CAS号: 2857937-59-6
• 分子量: 410.37
• 分類程式碼代碼: 12352200
• NACRES: NA.21

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C

说明

生化／生理作用

MYF-03-176 is an orally active, potent, irreversible pan-TEAD inhibitor that disrupts YAP-TEAD association by targeting TEAD palmitate pocket for covalent binding. MYF-03-176 suppresses NCI-H226 cellular TEAD transcriptional activity (IC50 = 11 nM by TEAD reporter assay), blocking TEAD-mediated target genes expression (CTGF, CYR61, ANKRD1) and suppression (BMF). MYF-03-176 effectively inhibits Hippo signaling-driven human lung mesothelioma NCI-H226 proliferaton in cultures (IC50 = 9 nM in 5 days) and in a xenograft model in mice in vivo (35 or 75 mg/kg b.i.d. p.o. for 4 wks).

Orally active, potent, irreversible pan-TEAD inhibitor that disrupts YAP-TEAD association and inhibits Hippo signaling-driven cancer proliferation in vitro and in vivo.

注意

Hygroscopic

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable