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SML3639

Sigma-Aldrich

CU-T12-9

≥98% (HPLC)

别名:

CU-T 12-9, N-Methyl-4-nitro-2-(4-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline

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About This Item

经验公式（希尔记法）:
C17H13F3N4O2
CAS号:
1821387-73-8
分子量:
362.31
MDL號碼:
MFCD30182292
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

-10 to -25°C

SMILES 字串

FC(F)(F)c1ccc(cc1)c2nc[n](c2)c3c(ccc(c3)[N+](=O)[O-])NC

InChI

1S/C17H13F3N4O2/c1-21-14-7-6-13(24(25)26)8-16(14)23-9-15(22-10-23)11-2-4-12(5-3-11)17(18,19)20/h2-10,21H,1H3

InChI 密鑰

LITXVDAFEYLWQE-UHFFFAOYSA-N

生化／生理作用

Activator of toll-like receptor signaling, selective for TLR1 and TLR2
CU-T12-9 is a potent activator of toll-like receptor signaling, selective for TLR1 and TLR2. CU-T12-9 binds selectively to toll-like receptors TLR1 and TLR2, facilitating the TLR1/2 heterodimeric complex formation and activating downstream signaling of NF-κB.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Kui Cheng et al.
Science advances, 1(3) (2015-06-24)
Toll-like receptor (TLR) agonists activate both the innate and the adaptive immune systems. These TLR agonists have been exploited as potent vaccine adjuvants and antitumor agents. We describe the identification and characterization of a small molecule, N-methyl-4-nitro-2-(4-(4-(trifluoromethyl)phenyl)-1 H-imidazol-1-yl)aniline (CU-T12-9), that
Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization
International Journal of Molecular Sciences, 23(10), 5478-5478 (2022)

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