SML3411

LY2828360

≥98% (HPLC)

• 别名: 8-(2-Chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine, LY 2828360
• 经验公式（希尔记法）: C₂₂H₂₇ClN₆O
• CAS号: 1231220-79-3
• 分子量: 426.94
• MDL號碼: MFCD28010855
• 分類程式碼代碼: 41121800
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear (Warmed)
• 儲存溫度: -10 to -25°C
• SMILES 字串: Clc1c(cccc1)c2[n](c4nc(nc(c4n2)N5CCN(CC5)C)C)C3CCOCC3
• InChI: 1S/C22H27ClN6O/c1-15-24-21(28-11-9-27(2)10-12-28)19-22(25-15)29(16-7-13-30-14-8-16)20(26-19)17-5-3-4-6-18(17)23/h3-6,16H,7-14H2,1-2H3
• InChI 密鑰: UCMNDPDJRSEZPL-UHFFFAOYSA-N

说明

生化／生理作用

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist that inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.

Potent and selective slowly acting G protein-biased CB2 cannabinoid agonist

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable