SML3234

GSK778 Hydrochloride

≥98% (HPLC)

• 别名: 4-{2-(Methoxymethyl)-1-[(R)-1-phenylethyl]-8-[(S)-pyrrolidin-3-ylmethoxy]-1H-imidazo[4,5-c]quinolin-7-yl}-3,5-dimethylisoxazole Hydrochloride, iBET-BD1 Hydrochloride
• 经验公式（希尔记法）: C₃₀H₃₃N₅O₃ · xHCl
• 分子量: 511.61 (free base basis)
• MDL號碼: MFCD33402173
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: C[C@H](C1=CC=CC=C1)N2C(COC)=NC3=C2C(C=C4OC[C@@H]5CNCC5)=C(N=C3)C=C4C6=C(C)ON=C6C
• InChI: 1S/C30H33N5O3/c1-18-29(20(3)38-34-18)24-12-25-23(13-27(24)37-16-21-10-11-31-14-21)30-26(15-32-25)33-28(17-36-4)35(30)19(2)22-8-6-5-7-9-22/h5-9,12-13,15,19,21,31H,10-11,14,16-17H2,1-4H3/t19-,21+/m1/s1
• InChI 密鑰: ZORLJXWXFABTPZ-CTNGQTDRSA-N

说明

生化／生理作用

GSK778 (iBET-BD1) is a potent and highly selective inhibitor of bromodomain BD1 of BRD2, BDR3, BRD4, BRDT. GSK778 (iBET-BD1) potently inhibits numerous cancer cells proliferation, inducing cell cycle arrest and apoptosis.

Potent and highly selective inhibitor of bromodomain BD1 of BRD2, BDR3, BRD4, BRDT

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable