SML3196

SU086

≥98% (HPLC)

• 别名: (2E)-3-(3-Nitrophenyl)-1-(2,4,6-trimethoxyphenyl)-2-propen-1-one
• 经验公式（希尔记法）: C₁₈H₁₇NO₆
• CAS号: 1017898-53-1
• 分子量: 343.33
• MDL號碼: MFCD03788900
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear (warmed)
• 儲存溫度: 2-8°C

说明

生化／生理作用

SU086 is a cell-permeable, non-toxic, bioavailable chalcone compound that decreases HSP90 levels and impairs glycolysis. SU086 is shown to inhibit prostate cancer cell growth, migration, and invasion in vitro (10 μM) through non-androgen receptor mediated pathways. SU086 displays favorable PK profile and synergizes with enzalutamide and abiraterone to decrease prostate cancer growth in vitro and in vivo. It is a potent inhibitor of selenoprotein thioredoxin reductases (TrxRs).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable