SML2821
DiFMUP
≥98% (HPLC)
别名:
6,8-Difluoro-4-methylumbelliferyl phosphate, 6,8-Difluoro-4-methyl-7-(phosphonooxy)-2H-1-benzopyran-2-one, 6,8-Difluoro-4-methyl-umbelliferyl phosphate, 6,8-Difluoro-4-methyl-umbelliferyl phosphate, 6,8-Difluoro-7-hydroxy-4-methylcoumarin phosphate
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About This Item
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生化／生理作用
DiFMUP (6,8-difluoro-4-methylumbelliferyl phosphate), a fluorinated analog of MUP, is a fluorescent synthetic substrate for continuous assessment of phosphatase activity. DiFMUP excitation/emission maxima are 358/450 nm.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Stefan Welte et al.
Analytical biochemistry, 338(1), 32-38 (2005-02-15)
The fluorogenic substrate 6,8-difluoro-4-methylumbiliferyl phosphate (DIFMUP) has been widely used for the detection of serine and threonine phosphatase activities. Here we describe the use of this substrate for the characterization of protein tyrosine phosphatases (PTPs) and for the screening for
John S Lazo et al.
The Journal of pharmacology and experimental therapeutics, 371(3), 652-662 (2019-10-12)
Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant processes. 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione (JMS-053) is a novel, potent, and selective PTP4A inhibitor
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