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Merck
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文件

SML2659

Sigma-Aldrich

Spastazoline

≥98% (HPLC)

别名:

(R)-N-(5-(tert-butyl)-1H-pyrazol-3-yl)-2-(3-isopropylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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About This Item

经验公式（希尔记法）:
C20H30N8
CAS号:
2351882-11-4
分子量:
382.51
MDL號碼:
MFCD31813810
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

生化／生理作用

Spastazoline is a cell penetrant, potent and selective ATP-competitive inhibitor of spastin.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

分析证书(COA)

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Rudolf Pisa et al.
Journal of the American Chemical Society, 141(14), 5602-5606 (2019-03-16)
The bump-hole approach is a powerful chemical biology strategy to specifically probe the functions of closely related proteins. However, for many protein families, such as the ATPases associated with diverse cellular activities (AAA), we lack structural data for inhibitor-protein complexes
Tommaso Cupido et al.
Nature chemical biology, 15(5), 444-452 (2019-02-20)
Spastin is a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein needed for cell division and intracellular vesicle transport. Currently, we lack chemical inhibitors to probe spastin function in such dynamic cellular processes. To design a chemical inhibitor of

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