SML1516

DS-437

≥98% (HPLC)

• 别名: 5′-S-[2-[[(Ethylamino)carbonyl]amino]ethyl]-5′-thio-adenosine
• 经验公式（希尔记法）: C₁₅H₂₃N₇O₄S
• CAS号: 1674364-87-4
• 分子量: 397.45
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825933
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSCCNC(NCC)=O)O3
• InChI: 1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10+,11?,14-/m1/s1
• InChI 密鑰: CACMCLIHCDTJHL-XNZUMOJTSA-N

说明

應用

DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.

生化／生理作用

DS-437 inhibits regulatory T cells (Tregs) function and methylation of forkhead box P3 (FOXP3) in 293T cells. DS-437 in combination with anti-p185erbB2/neu antibody 4D5 reduces tumor growth in CT26HER2 tumor-bearing mice.

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC₅₀ 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.

其他說明

DS-437 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the DS-437 probe summary on the Chemical Probes Portal website.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable