SML1317

XAP044

≥98% (HPLC)

• 别名: 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one, XAP 044
• 经验公式（希尔记法）: C₁₅H₉IO₄
• CAS号: 196928-50-4
• 分子量: 380.13
• MDL號碼: MFCD00525548
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825781
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: protect from light
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
• InChI: 1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
• InChI 密鑰: XXZKJJYWINSUMJ-UHFFFAOYSA-N

说明

生化／生理作用

XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7′s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.

XAP044 is a brain penetrant, potent and selective mGlu7 antagonist.

其他說明

Light sensitive. This compound has Iodine and should be kept in the dark.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable