SML1277

Geldanamycin-FITC

≥98% (HPLC), from Streptomyces hygroscopicus

• 别名: Geldanamycin, fluorescein isothiocyanate labeled
• 经验公式（希尔记法）: C₅₅H₆₃N₅O₁₃S
• 分子量: 1034.18
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 生物源: Streptomyces hygroscopicus
• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: protect from light
• 顏色: yellow to yellow-orange
• 溶解度: DMSO: soluble 5 mg/mL
• 抗生素活性譜: neoplastics
• 作用方式: enzyme | inhibits
• 儲存溫度: −20°C

说明

一般說明

Chemical structure: benzenoid

生化／生理作用

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable