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SML0574

Sigma-Aldrich

YM-298198 hydrochloride

≥98% (HPLC)

别名:

6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride

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About This Item

经验公式（希尔记法）:
C18H22N4OS · HCl
CAS号:
1216398-09-2
分子量:
378.92
MDL號碼:
MFCD08703122
分類程式碼代碼:
12352200
PubChem物質ID:
329825561
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 5 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

Cl.CN(C1CCCCC1)C(=O)c2sc3nc4ccc(N)cc4n3c2C

InChI

1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H

InChI 密鑰

WYTJVUVCSUWZTH-UHFFFAOYSA-N

生化／生理作用

YM-298198 is an orally active, noncompetitive mGlu1 receptor antagonist. The compound inhibits glutamate-induced inositol phosphate production in NIH3T3 cells (IC50 = 16 nM). YM-298198 displays analgesic and antinociceptive properties in vivo.

特點和優勢

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Haein Weon et al.
Life sciences, 188, 110-117 (2017-09-09)
Both N-type and P/Q-type voltage-gated Ca (S)-3,5-Dihydroxyphenylglycine (DHPG; 10μM for 5min), the group I mGluR agonist, was used to induce LTP of excitatory postsynaptic currents that were evoked in the Vo neurons by stimulating the trigeminal track. Weak blockade of

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