SML0475

CGP36742

≥97% (NMR)

• 别名: P-(3-Aminopropyl)-P-butyl-phosphinic acid, SGS 742
• 经验公式（希尔记法）: C₇H₁₈NO₂P
• CAS号: 123690-78-8
• 分子量: 179.20
• MDL號碼: MFCD00882735
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825430
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥97% (NMR)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: H₂O: 10 mg/mL (clear solution, warmed)
• 儲存溫度: room temp
• SMILES 字串: CCCCP(O)(=O)CCCN
• InChI: 1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)
• InChI 密鑰: ONNMDRQRSGKZCN-UHFFFAOYSA-N

说明

生化／生理作用

CGP36742 was the first orally active GABAB-selective antagonist. The IC₅₀ for blocking GABAergic transmission is 36 μM. Oral administration of CGP36742 in rats blocks baclofen-induced neuronal depression, and reduces learning deficit and passive avoidance in an olfactory bulbectomy depression model.

特點和優勢

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安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302 - H319
• 防範說明: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable