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Merck

SML0088

Sigma-Aldrich

WZ811

≥98% (HPLC)

别名:

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

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About This Item

经验公式(希尔记法):
C18H18N4
CAS号:
分子量:
290.36
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to tan

溶解度

DMSO: ≥7 mg/mL

儲存溫度

2-8°C

SMILES 字串

C(Nc1ccccn1)c2ccc(CNc3ccccn3)cc2

InChI

1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)

InChI 密鑰

KBVFRXIGQQRMEF-UHFFFAOYSA-N

生化/生理作用

WZ811 is a potent, specific antagonist of CXCR4 (IC50 = 0.3 nM). WZ811 blocks SDF-1 mediated changes in cellular cAMP levels in U87 glioma cells (IC50 = 1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (IC50 = 5.2 nM).

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Chun-Hui Zheng et al.
Cell biology international, 42(10), 1386-1394 (2018-07-05)
CXCR4 has been shown to play a key role in the metastasis of non-small cell lung cancer (NSCLC). And CXCR may be associated with the Hippo-Yes kinase-associated protein (YAP) pathway, thus involving in the occurrence and progression of NSCLC. This
Andrew J Shepherd et al.
PloS one, 8(9), e76698-e76698 (2013-10-03)
Infection with human immunodeficiency virus-1 (HIV-1) within the brain has long been known to be associated with neurodegeneration and neurocognitive disorder (referred as HAND), a condition characterized in its early stages by declining cognitive function and behavioral disturbances. Mechanistically, the
Miodrag Dragoj et al.
Cellular oncology (Dordrecht), 40(1), 47-62 (2016-11-09)
Current high lung cancer mortality rates are mainly due to the occurrence of metastases and therapeutic resistance. Therefore, simultaneous targeting of these processes may be a valid approach for the treatment of this type of cancer. Here, we assessed relationships
Miodrag Dragoj et al.
Investigational new drugs, 35(6), 718-732 (2017-07-25)
Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. At the time of diagnosis, a large percentage of NSCLC patients have already developed metastasis, responsible for extremely high mortality rates. CXCR4 receptor and focal adhesion kinase
Thomas A Werner et al.
British journal of cancer, 117(12), 1837-1845 (2017-11-08)
Medullary thyroid carcinoma (MTC) is a rare and challenging endocrine malignancy. Once spread, the therapeutic options are limited and the outcome poor. For these patients, the identification of new druggable biological markers is of great importance. Here, we investigated the

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