SML0077

VU591

≥98% (HPLC)

• 别名: 2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
• 经验公式（希尔记法）: C₁₆H₁₂N₆O₅
• CAS号: 1222810-74-3
• 分子量: 368.30
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825139
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to tan
• 溶解度: DMSO: ≥12 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: [O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
• InChI: 1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)
• InChI 密鑰: ZQPXNYLXYNRFNP-UHFFFAOYSA-N
• 基因資訊: human ... KCNJ1(3758)

说明

應用

VU591 may be used in cell signaling studies.

生化／生理作用

ROMK (Kir 1.1) inhibitor

VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable