SML0066

NGB 2904 hydrochloride

≥98% (HPLC)

• 别名: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride
• 经验公式（希尔记法）: C₂₈H₂₉Cl₂N₃O·HCl
• CAS号: 189061-11-8
• 分子量: 530.92
• MDL號碼: MFCD09971107
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825130
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to tan
• 溶解度: DMSO: ≥25 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
• InChI: 1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
• InChI 密鑰: PFIWYJNBKGCVFM-UHFFFAOYSA-N

说明

應用

NGB 2904 hydrochloride may be used in cell signaling studies.

生化／生理作用

Inhibition of dopamine D₃ receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.

NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

特點和優勢

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable