SBR00068

Streptomycin Ready Made Solution

100 mg/mL in water

• CAS号: 3810-74-0
• 分類程式碼代碼: 51281624
• NACRES: NA.76

属性

• 形狀: liquid
• 品質等級: 200
• 比活性: (Antibacterial)
• 濃度: 100 mg/mL in water
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C
• SMILES 字串: [S](=O)(=O)(O)O.[S](=O)(=O)(O)O.[S](=O)(=O)(O)O.N([C@@H]4[C@@H](O[C@H]([C@@H]([C@H]4O)O)CO)O[C@H]5[C@@H](O[C@H]([C@]5(O)C=O)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H]([C@@H]6O)O)N=C(N)N)O)N=C(N)N)C.N([C@@H]1[C@@H](O[C@H]([C@@H]([C@H]1O)O)CO)O[C@H]2[C@@H](O[C@H]([
• InChI: 1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-
• InChI 密鑰: QTENRWWVYAAPBI-YZTFXSNBSA-N

说明

一般說明

Chemical structure: aminoglycoside

應用

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50 μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

生化／生理作用

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

儲存和穩定性

• Streptomycin ready made solution contains 100 mg/mL streptomycin sulfate in water.
• Streptomycin: sulfate salt ratio is 1:1.5.
• The product is packed under aseptic conditions.

安全信息

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H361fd
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 2
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3