SAB5701932

Anti-Phospho-SHC1-Y427 antibody produced in rabbit

• 分類程式碼代碼: 12352203

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: liquid
• 物種活性: mouse, human
• 濃度: 2.53 mg/mL
• 技術: western blot: 1:500-1:2000
• UniProt登錄號: P29353
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pTyr427)
• 基因資訊: human ... SHC1(6464)

说明

一般說明

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

免疫原

A phospho specific peptide corresponding to residues surrounding Y427 of human SHC1.

外觀

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable