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Merck
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主要文件

SAB5200085

Sigma-Aldrich

Anti-ING1 antibody produced in rabbit

250 μg/mL, affinity isolated antibody

别名:

Anti- p47ING1a, Anti-ING1, Anti-growth inhibitor ING1, Anti-p33 ING1, Anti-p33ING1b, Anti-p47

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous glycerol solution

分子量

antigen predicted mol wt 33 kDa

种属反应性

mouse, human

浓度

250 μg/mL

技术

indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

mouse ... Ing1(26356)

一般描述

Inhibitor of growth-family member 1 (ING1) possesses plant homeodomains (PHDs). The gene ID of the protein is 26356.

特异性

Detects a ~33 kDa protein corresponding to the molecular mass of p33 ING1 on SDS PAGE immunoblots.

免疫原

Mouse p33 ING1 N-terminal peptide –KLH conjugates

生化/生理作用

Inhibitor of growth-family member 1 (ING1) may take part in chromatin remodeling. It is a part of histone acetyltransferase complex and acts as an epigenetic modulator. Like the other members of its family, ING1 also functions as a tumor suppressor.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

TBS, 50% glycerol, 0.09% sodium azide

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Masato Takahashi et al.
Cancer research, 62(8), 2203-2209 (2002-04-17)
The candidate tumor suppressor p33(ING1) plays an important role in inducinggrowth arrest at G(0)-G(1) phase of the cell cycle and/or promoting apoptosis in cancerous cells. p33(ING1) is reported to act as a transcriptional cofactor by associating with tumor suppressor p53
Uma Karthika Rajarajacholan et al.
PLoS biology, 11(3), e1001502-e1001502 (2013-03-09)
The INhibitor of Growth (ING) proteins act as type II tumor suppressors and epigenetic regulators, being stoichiometric members of histone acetyltransferase and histone deacetylase complexes. Expression of the alternatively spliced ING1a tumor suppressor increases >10-fold during replicative senescence. ING1a overexpression

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