推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
分子量
antigen predicted mol wt 33 kDa
种属反应性
mouse, human
浓度
250 μg/mL
技术
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Ing1(26356)
一般描述
Inhibitor of growth-family member 1 (ING1) possesses plant homeodomains (PHDs). The gene ID of the protein is 26356.
特异性
Detects a ~33 kDa protein corresponding to the molecular mass of p33 ING1 on SDS PAGE immunoblots.
免疫原
Mouse p33 ING1 N-terminal peptide –KLH conjugates
生化/生理作用
Inhibitor of growth-family member 1 (ING1) may take part in chromatin remodeling. It is a part of histone acetyltransferase complex and acts as an epigenetic modulator. Like the other members of its family, ING1 also functions as a tumor suppressor.
特点和优势
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外形
TBS, 50% glycerol, 0.09% sodium azide
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Masato Takahashi et al.
Cancer research, 62(8), 2203-2209 (2002-04-17)
The candidate tumor suppressor p33(ING1) plays an important role in inducinggrowth arrest at G(0)-G(1) phase of the cell cycle and/or promoting apoptosis in cancerous cells. p33(ING1) is reported to act as a transcriptional cofactor by associating with tumor suppressor p53
Uma Karthika Rajarajacholan et al.
PLoS biology, 11(3), e1001502-e1001502 (2013-03-09)
The INhibitor of Growth (ING) proteins act as type II tumor suppressors and epigenetic regulators, being stoichiometric members of histone acetyltransferase and histone deacetylase complexes. Expression of the alternatively spliced ING1a tumor suppressor increases >10-fold during replicative senescence. ING1a overexpression
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