共軛
unconjugated
品質等級
抗體產品種類
primary antibodies
無性繁殖
SK7, monoclonal
形狀
buffered aqueous solution
物種活性
( Human), (Non-human primates)
濃度
1 mg/ml
技術
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同型
IgG1κ
UniProt登錄號
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... CD3E(916)
一般說明
CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
特異性
The mouse monoclonal antibody SK7 recognizes an extracellular epitope on the CD3 antigen on mature human T cells. This antibody reacts with the epsilon chain of the CD3 complex. The monoclonal antibodies SK7 and UCHT1 recognize overlapping epitopes.
免疫原
Human thymocytes
外觀
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
準備報告
Purified by protein-A affinity chromatography.
儲存和穩定性
Store at 2-8°C. Do not freeze.
其他說明
The antibody solution should be gently mixed before use.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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