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Key Documents

SAB4702025

Monoclonal Anti-EGFR PE produced in mouse

new

别名:

EGF-R, ERBB1, Her1, NISBD2, PIG61

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About This Item

分類程式碼代碼:
12352203

共軛

phycoerythrin (R-PE) conjugate

品質等級

抗體產品種類

primary antibodies

無性繁殖

EGFR1, monoclonal

形狀

buffered aqueous solution

物種活性

horse, ( Human)

技術

flow cytometry: suitable

同型

IgG2bκ

UniProt登錄號

儲存溫度

2-8°C

目標翻譯後修改

unmodified

基因資訊

human ... EGFR(1956)

一般說明

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.

特異性

The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273.

免疫原

Human epidermoid carcinoma line A431

外觀

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

準備報告

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

儲存和穩定性

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

其他說明

The antibody solution should be gently mixed before use.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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