共軛
biotin conjugate
品質等級
抗體產品種類
primary antibodies
無性繁殖
9E10, monoclonal
形狀
buffered aqueous solution
物種活性
( Human), (Tagged fusion proteins in all species)
濃度
1 mg/ml
技術
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同型
IgG1
UniProt登錄號
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... MYC(4609)
一般說明
The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells.
特異性
The antibody 9E10 can be used to detect the c-Myc tag.
免疫原
Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-Myc.
外觀
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
準備報告
Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
儲存和穩定性
Store at 2-8°C. Do not freeze.
其他說明
The antibody solution should be gently mixed before use.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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