推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
MEM-101A, monoclonal
形狀
buffered aqueous solution
物種活性
human, pig, canine
濃度
1 mg/mL
技術
flow cytometry: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... ITGB1(3688)
一般說明
Cluster of differentiation 29 (CD29), also known as integrin subunit β 1 (ITGB1), is a mechanosensor, encoded by the gene mapped to human chromosome 10p11.22. It is present in both normal cells and tumor-associated cells. The encoded protein has ubiquitous expression with a molecular mass of 130kDa.
The antibody MEM-101A reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 is broadly expressed on majority of hematopoietic and non-hematopoietic cells (leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells and mast cells).
免疫原
Raji Burkitt′s lymphoma cell line
應用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)
Flow cytometry/Cell sorting (1 paper)
生化/生理作用
Cluster of differentiation 29 (CD29) acts as an adhesive molecule in the development of de novo focal contact, keratinocyte migration and re-epithelialization of wound tissue. CD29 with/without CD27 induce apoptosis, in association with a multifunctional protein galectin (Gal)-3.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer
International Journal of Molecular Sciences, 17 (2016)
Genomic Aberrations Associated with Erlotinib Resistance in Non-small Cell Lung Cancer Cells
Anticancer Research, 33, 5223-5233 (2013)
β1 integrin signaling in asymmetric migration of keratinocytes under mechanical stretch in a co-cultured wound repair model
BioMedical Engineering OnLine, 15 (2016)
CD29 and CD7 Mediate Galectin-3-Induced Type II T-Cell Apoptosis
Cancer Research, 63, 8302-8311 (2003)
PloS one, 12(10), e0186628-e0186628 (2017-10-19)
SHARPIN (Shank-Associated RH Domain-Interacting Protein) is a component of the linear ubiquitin chain assembly complex (LUBAC), which enhances TNF-induced NF-κB activity. SHARPIN-deficient (Sharpincpdm/cpdm) mice display multi-organ inflammation and chronic proliferative dermatitis (cpdm) due to TNF-induced keratinocyte apoptosis. In cells, SHARPIN
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