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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 110 kDa
物種活性
human, rat, mouse
濃度
~1 mg/mL
技術
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr749/pTyr681)
基因資訊
human ... MERTK(10461) , TYRO3(7301)
一般說明
Tyro3 (TYRO3 protein tyrosine kinase) is an 890 amino acid protein that belongs to the TAM (Tyro3, Axl and Mer) receptor family. Tyro3 is mapped to human chromosome 15q15. It is highly expressed in the nervous system like the neocortex, hippocampus and cerebellum. It is also present in monocytes, macrophages, platelets, dendritic cells and NK cells, breast, ovary, testis, lung, kidney, retinal pigment epithelium and osteoclasts.
免疫原
The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681.
Immunogen Range: 716-765
Immunogen Range: 716-765
生化／生理作用
Tyro3 (TYRO3 protein tyrosine kinase) serves as a therapeutic target in breast cancer. This protein is involved in spermatogenesis, immunoregulation, and phagocytosis. It controls disseminated prostate cancer cellular dormancy. TYRO3 helps in the survival and transport of of gonadotropin-releasing hormone (GnRH) neurons within the forebrain. Mutation in TYRO3 result in retinitis pigmentosa.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A novel MERTK mutation causing retinitis pigmentosa.
Al-Khersan H, et al.
Graefe'S Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 255(8), 1613-1619 (2017)
Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression.
Duan Y, et al.
International Journal of Oncology, 48(1), 358-366 (2016)
TYRO3 (TYRO3 protein tyrosine kinase).
Jacobsen KM, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 14(11) (2010)
Mer tyrosine kinase regulates disseminated prostate cancer cellular dormancy.
Cackowski FC, et al.
Journal of Cellular Biochemistry, 118(4), 891-902 (2017)
TYRO3 as a potential therapeutic target in breast cancer.
Ekyalongo RC, et al.
Anticancer Research, 34(7), 3337-3345 (2014)
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