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Merck
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Key Documents

SAB4504388

Sigma-Aldrich

Anti-phospho-eIF2 α (pSer51) antibody produced in rabbit

affinity isolated antibody

别名:

Anti-EIF-2, Anti-EIF-2A, Anti-EIF-2alpha, Anti-EIF2, Anti-EIF2A

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 36 kDa

物種活性

human, mouse, rat

濃度

~1 mg/mL

技術

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pSer51)

基因資訊

human ... EIF2S1(1965)

一般說明

EIF2S1 (eukaryotic translation initiation factor 2 subunit α) is a heterotrimeric protein and a regulatory subunit of eIF2 . eIF2 has three general subunits- α, βand γ . eIF2α is located on human chromosome 14q23 .

免疫原

The antiserum was produced against synthesized peptide derived from human eIF2 alpha around the phosphorylation site of Ser51.

Immunogen Range: 21-70

應用

Anti-phospho-eIF2 α(pSer51) antibody has been used in western blotting and immunohistochemistry.

生化/生理作用

EIF2S1 (eukaryotic translation initiation factor 2 subunit α) acts as a modulator in apoptosis signaling pathway . During endoplasmic reticulum stress, eIF2α plays a major role in signaling pathways in the development of tumor .

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

Translational regulator eIF2? in tumor
Zheng Q, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 35(7), 6255-6264 (2014)
Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats
Ko AR, et al.
Neuroscience, 307, 199-214 (2015)
Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response
Larroquette F, et al.
Human Molecular Genetics, 24(22), 6515-6529 (2015)
Isabella R Straub et al.
Human molecular genetics, 30(8), 687-705 (2021-03-23)
Mutations in CHCHD10, coding for a mitochondrial intermembrane space protein, are a rare cause of autosomal dominant amyotrophic lateral sclerosis. Mutation-specific toxic gain of function or haploinsufficiency models have been proposed to explain pathogenicity. To decipher the metabolic dysfunction associated
The Role of the PERK/eIF2?/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress
Rozpedek W, et al.
Current Molecular Medicine, 16(6), 533-544 (2016)

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