SAB4504153
Anti-phospho-CXCR4 (pSer339) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-CD184, Anti-D2S201E, Anti-FB22, Anti-HM89, Anti-HSY3RR, Anti-LAP-3, Anti-LAP3, Anti-LCR1, Anti-LESTR, Anti-NPY3R, Anti-NPYR, Anti-NPYRL, Anti-NPYY3R, Anti-WHIM, Anti-WHIMS, Anti-WHIMS1
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所有图片(7)
About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 39 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer339)
基因資訊
human ... CXCR4(7852)
一般說明
The CXC chemokine receptor 4 (CXCR4) is a G-protein coupled 7-transmembrane (TM) chemokine receptor. It is made up of 352 amino acids. CXCR4 is expressed on the surface of T-cells, B-cells, monocytes, neutrophils and dendritic cells. This gene is located on human chromosome 2q22.1.
免疫原
The antiserum was produced against synthesized peptide derived from human CXCR4 around the phosphorylation site of Ser339.
Immunogen Range: 303-352
Immunogen Range: 303-352
應用
Anti-phospho-CXCR4 (pSer339) antibody has been used in immunohistochemical analysis.
生化／生理作用
The CXC chemokine receptor 4 (CXCR4) participates in the progression of the embryo, immune and inflammatory responses, modulation of hematopoiesis, human immunodeficiency virus infection and stimulation of angiogenesis. CXCR4 and its ligand, CXCL12 is involved in the synthesis of B-cell, myelopoiesis, integrin activation and chemotaxis.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons.
Yang S, et al.
Development, dev-098145 (2013)
Ben Hitchinson et al.
Science signaling, 11(552) (2018-10-18)
Repeated dosing of drugs targeting G protein-coupled receptors can stimulate antagonist tolerance, which reduces their efficacy; thus, strategies to avoid tolerance are needed. The efficacy of AMD3100, a competitive antagonist of the chemokine receptor CXCR4 that mobilizes leukemic blasts from
The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors.
Chao Z, et al.
Chinese Journal of Cancer, 36(1), 80-80 (2017)
Saran Chattapadhyaya et al.
Journal of cellular physiology, 235(3), 2619-2630 (2019-09-11)
Megakaryopoiesis is the process of formation of mature megakaryocytes that takes place in the bone marrow niche resulting in the release of platelets into the peripheral blood. It has been suggested that cell to cell communication in this dense bone
The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential.
Peng D, et al.
European Journal of Medicinal Chemistry, 149, 148-169 (2018)
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