SAB4503615
Anti-EDG5 antibody produced in rabbit
affinity isolated antibody
别名:
Endothelial differentiation G-protein coupled receptor 5, S1P receptor Edg-5, S1P2, Sphingosine 1-phosphate receptor 2, Sphingosine 1-phosphate receptor Edg-5
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About This Item
共軛:
unconjugated
application:
ELISA
WB
WB
無性繁殖:
polyclonal
物種活性:
rat, human, mouse
citations:
4
技術:
ELISA: 1:40000
western blot: 1:500-1:1000
western blot: 1:500-1:1000
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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 38 kDa
物種活性
rat, human, mouse
濃度
~1 mg/mL
技術
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... S1PR2(9294)
一般說明
Anti-EDG5 Antibody detects endogenous levels of total EDG5 protein.
EDG5/ S1PR2 (sphingosine-1-phosphate receptor 2), a pleiotropic lipid mediator is abundantly expressed in most of the tissues. S1PR2 codes for a 353 amino acid sphingosine-1-phosphate receptor 2 and is located on human chromosome 19p13.2.
EDG5/ S1PR2 (sphingosine-1-phosphate receptor 2), a pleiotropic lipid mediator is abundantly expressed in most of the tissues. S1PR2 codes for a 353 amino acid sphingosine-1-phosphate receptor 2 and is located on human chromosome 19p13.2.
免疫原
The antiserum was produced against synthesized peptide derived from human EDG5.
Immunogen Range: 261-310
Immunogen Range: 261-310
生化／生理作用
In NB (neuroblastoma), EDG5/ S1PR2 (sphingosine-1-phosphate receptor 2) helps in the expression of S1P-induced vascular endothelial growth factor. It promotes the Rho/Rho-kinase pathway. S1PR2 participates in S1P-induced platelet aggregation. S1PR2 is essential for normal auditory function as it is a part of the sphingosine-1-phosphate signaling (S1P) pathway.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Antitumor activity of a novel sphingosine-1-phosphate 2 antagonist, AB1, in neuroblastoma.
Li MH, et al.
Journal of Pharmacology and Experimental Therapeutics, 354(3), 261-268 (2015)
The conserved p. Arg108 residue in S1PR2 (DFNB68) is fundamental for proper hearing: evidence from a consanguineous Iranian family.
Hofrichter MA, et al.
BMC Medical Genetics, 19(1), 81-81 (2018)
S1P2 receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology.
Sumida GM and Stamer WD
American Journal of Physiology. Cell Physiology, 300(5), C1164-C1171 (2011)
Voahanginirina Randriamboavonjy et al.
Basic research in cardiology, 104(3), 333-340 (2009-01-14)
Sphingosine-1-phosphate (S1P) is known to affect platelet responsiveness but the receptor mediating these effects and the mechanisms involved are poorly understood. This study was undertaken to examine S1P receptor expression in human platelets as well as potential changes associated with
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