推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 99 kDa
物種活性
human, rat, mouse
濃度
~1 mg/mL
技術
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... RABEP1(9135)
一般說明
Anti-RABEP1 Antibody detects endogenous levels of total RABEP1 protein.
The gene RABEP1 (Rab GTPase-binding effector protein 1) is mapped to human chromosome 17p13.2. The encoded protein has two Rab5-binding sites.
The gene RABEP1 (Rab GTPase-binding effector protein 1) is mapped to human chromosome 17p13.2. The encoded protein has two Rab5-binding sites.
免疫原
The antiserum was produced against synthesized peptide derived from human RABEP1.
Immunogen Range: 549-598
Immunogen Range: 549-598
生化／生理作用
RABEP1 (Rab GTPase-binding effector protein 1) is an effector of Rab5 and plays an important role in homotypic and heterotypic fusions of early endosomes. Absence of RABEP1 suppresses Rab5-associated early endosome fusion.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
PDGFRB-rearranged T-lymphoblastic leukemia/lymphoma occurring with myeloid neoplasms: the missing link supporting a stem cell origin.
Sarah L Ondrejka et al.
Haematologica, 99(9), e148-e151 (2014-06-22)
Zhe Zhang et al.
eLife, 3, doi:10-doi:10 (2014-06-25)
Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in endocytosis. The Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain (Rabex-5CC) and activated by the Rabaptin-5 C2-1 domain (Rabaptin-5C21) with yet unknown mechanism.
Mi Hee Park et al.
Experimental & molecular medicine, 47, e200-e200 (2015-12-19)
Endocytosis is differentially regulated by hypoxia-inducible factor-1α (HIF-1α) and phospholipase D (PLD). However, the relationship between HIF-1α and PLD in endocytosis is unknown. HIF-1α is degraded through the prolyl hydroxylase (PHD)/von Hippel-Lindau (VHL) ubiquitination pathway in an oxygen-dependent manner. Here
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