推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 24 kDa
物種活性
human, mouse
濃度
~1 mg/mL
技術
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CLDN2(9075)
一般說明
Anti-Claudin 2 Antibody detects endogenous levels of total Claudin 2 protein.
Claudin-2 is one of the pore-forming claudins. It is a member of the claudin family of proteins. Claudin-2 is present in the proximal tubules. It is mapped to human chromosome Xq22.
免疫原
The antiserum was produced against synthesized peptide derived from human Claudin 2.
Immunogen Range: 181-230
Immunogen Range: 181-230
應用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
生化／生理作用
The tetraspan membrane protein encoded by claudin multigene controls paracellular permeability and maintaining cell polarity in epithelial and endothelial cell sheets. In MDCK (madin-darby canine kidney cells) II cells, claudin-2 participates in the generation of aqueous pores with high conductance.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The claudins
Lal-Nag M and Morin P J
Genome Biology (2009)
Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells
Furuse M, et al.
The Journal of Cell Biology, 153(2), 263-272 (2001)
Inga B Christensen et al.
Frontiers in physiology, 4, 344-344 (2013-12-19)
The choroid plexus epithelium (CPE) has served as a model-epithelium for cell polarization and transport studies and plays a crucial role for cerebrospinal fluid (CSF) production. The normal luminal membrane expression of Na(+),K(+)-ATPase, aquaporin-1 and Na(+)/H(+) exchanger 1 in the
Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-? Treated Cell Monolayers
Zhang C, et al.
International Journal of Molecular Sciences, 18(1) (2017)
Tumor necrosis factor-? induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions
Amoozadeh Y, et al.
American Journal of Physiology. Cell Physiology, 309(1), C38-C50 (2015)
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