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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 64 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... FZD5(7855)
一般說明
Anti-FZD5 Antibody detects endogenous levels of total FZD5 protein.
The FZD5 (frizzled class receptor 5) gene encodes a receptor FZ5 for Wnt proteins and is mapped to human chromosome 2q33.3.
免疫原
The antiserum was produced against synthesized peptide derived from human FZD5.
Immunogen Range: 31-80
Immunogen Range: 31-80
生化/生理作用
Fzd5 (frizzled class receptor 5) is a receptor component for the canonical and non-canonical Wnt signaling pathways which is necessary for cell proliferation and cell differentiation. Fzd5 might serve as an important biomarker for eye malformation. The Wnt5a-Fz5 complex is known to support the functions of innate immunity. Fzd5 along with Gcm1 (chorion-specific transcription factor) is involved in a feedback mechanism that regulates trophoblast differentiation and chorionic branching in placenta.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
nwg
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Wnt5a-Rac1-NF-κB homeostatic circuitry sustains innate immune functions in macrophages.
Journal of Immunology, 192(9), 4386-4397 (2014)
A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma
Human Molecular Genetics, 25(7), 1382-1391 (2016)
Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ε and frizzled5.
The Journal of Biological Chemistry, 289(34), 23520-23533 (2014)
A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta
PLoS Biology, 11(4), e1001536-e1001536 (2013)
Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes
European Journal of Human Genetics, 14(12), 1280-1280 (2006)
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