推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 58 kDa
物種活性
mouse, rat, human
濃度
~1 mg/mL
技術
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TH(7054)
一般說明
Anti-Tyrosine Hydroxylase Antibody detects endogenous levels of total Tyrosine Hydroxylase protein.
The TH (tyrosine Hydroxylase) gene codes for a homotetramer that contains catalytic, regulatory, and tetramerization domains in each of its subunits.
免疫原
The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase.
Immunogen Range: 10-59
Immunogen Range: 10-59
生化／生理作用
The conversion of l-tyrosine into l-DOPA is catalyzed by tyrosine hydroxylase (TH), which is the rate-limiting step in the in the synthesis of catecholamines such as dopamine and also other necessary hormones and neuromodulators. TH enzyme deficiency results in low levels of dopamine, which is characterised in Parkinson′s disease.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.
Jorge-Finnigan A
The Journal of Biological Chemistry, 292(34), 14092-14107 (2017)
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins.
Ghorbani S
Amino Acids, 48(5), 1221-1229 (2016)
Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor.
Kumar AS
The Journal of Biological Chemistry, 291(23), 12310-12321 (2016)
Izel Tekin et al.
Parkinsonism & related disorders, 23, 86-90 (2016-01-07)
Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis. We investigated whether the presence of a common TH polymorphism
Wenyan Zou et al.
Translational neurodegeneration, 8, 7-7 (2019-03-15)
Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson's disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD. Recent studies have revealed an essential role of glymphatic
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