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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 12 kDa
物種活性
rat, mouse, human
濃度
~1 mg/mL
技術
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... BR44L(51660)
一般說明
MPC1 (mitochondrial pyruvate carrier 1) gene is mapped to human chromosome 6q27. MPC1 encodes a 12kDa, protein containing five exons and two membrane spanning α helixes. Anti-BRP44L Antibody detects endogenous levels of total BRP44L protein.
免疫原
The antiserum was produced against synthesized peptide derived from human BRP44L.
Immunogen Range: 11-60
Immunogen Range: 11-60
應用
Anti-BRP44L antibody produced in rabbit has been used to check the effect of mitochondrial TOM70 (translocase of the outer membrane protein 70) on MPC1 (mitochondrial pyruvate carrier 1) expression.
生化／生理作用
MPC1 (mitochondrial pyruvate carrier 1) is a key player in pyruvate metabolism. It transports pyruvate into the inner mitochondrial matrix. Lowered MPC1 expression, elevates glycolysis due to a shift in metabolism to fatty acid oxidation. This accounts for the pathogenesis of cancer and other diseases. Downregulation of this gene is observed in colon adenocarcinoma.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
Sandoval IT, et al.
eLife, 6(28), e22706-e22706 (2017)
Defective expression of the mitochondrial-trna modifying enzyme GTPBP3 triggers AMPK-mediated adaptive responses involving complex I assembly factors, uncoupling protein 2, and the mitochondrial pyruvate carrier
Martinez-Zamora A, et al.
PLoS ONE, 10(12), e0144273-e0144273 (2015)
TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer
Filadi R, et al.
Current Biology, 28(3), 369-382 (2018)
Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells
Li X, et al.
Testing, 8(28), 46363-46363 (2017)
Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas
Li Y, et al.
Oncotarget, 8(1), 1058-1073 (2017)
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